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Prevalence of aac(6')-Ib-cr plasmid-mediated and chromosome-encoded fluoroquinolone resistance in Enterobacteriaceae in Italy

Author(s): Frasson Ilaria | Cavallaro Antonietta | Bergo Cristina | Richter Sara N | Palù Giorgio

Journal: Gut Pathogens
ISSN 1757-4749

Volume: 3;
Issue: 1;
Start page: 12;
Date: 2011;
Original page

Keywords: aac(6')-Ib-cr | fluoroquinolones | plasmid-mediated resistance | Gram-negative

Abstract The spread of aac(6')-Ib-cr plasmid-mediated quinolone resistance determinants was evaluated in 197 enterobacterial isolates recovered in an Italian teaching hospital. The aac(6')-Ib-cr gene was found exclusively in Escherichia coli strains. The gene was located on a plasmid which presented additional ESBL genes. Most of the clinical strains were clonally related and displayed three point mutations at the topoisomerase level which conferred high resistance to fluoroquinolones.
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