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Prevalence of Multidrug Efflux Pump Requiring Ciprofloxacin, Ofloxacin and Pefloxacin as Substrates, Among Clinical Isolates of Pseudomonas aeruginosa

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Author(s): Omoregie, R. | Airueghionmon, D. J. U. | Okonkwo, J. O. | Airueghionmon, U.– E. | Ibeh, I. N. | Ogefere, H. O.

Journal: Malaysian Journal of Microbiology
ISSN 1823-8262

Volume: 3;
Issue: 2;
Start page: 37;
Date: 2007;
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Keywords: Efflux pump | Reserpine | Fluoroquinolones | Pseudomones aeruginosa

ABSTRACT
Forty two consecutive clinical isolates of Pseudomonas aeruginosa were screened for the presence of reserpine inhibited multidrug (MDR) efflux pump, utilizing ciprofloxacin ofloxacin and/or pefloxacin as substrates, by determining the minimum inhibitory concentration in the presence and absence of 100 mg/L reserpine. The result showed that 50% of the Pseudomonas aeruginosa isolates possessed reserpine inhibited MDR efflux pump. MDR efflux pump requiring ofloxacin (40.48%) were significantly (p

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