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Preventing Effects of Wheat Germ Oil on Sex Hormones, Liver Enzymes, Lipids and Proteins in Rat Serum Following Treatment with p-Nonylphenol

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Author(s): M. Soleimani Mehranjani | M.H. Abnosi | A. Naderi | M. Mahmodi

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 7;
Issue: 8;
Start page: 1406;
Date: 2007;
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Keywords: proteins | liver enzymes | sex hormones | wheat germ oil | p-nonylphenol | lipids

ABSTRACT
The aim of this study is to investigate the preventing effect of wheat germ oil as a rich source of vitamin E on the serum biochemical factors in the rats exposed to para-nonylphenol. Four groups (n = 6) of male Wistar rats was orally given para-nonylphenol (200 mg kgG-1dayG-1) for 70 days. After treatment the blood samples were obtained and LH, FSH, testosterone, progesterone and estrogen, transaminases, phosphatases, LDH, triglyceride, cholesterol, HDL-cholestrol and protein analysis were carried out. Para-nonylphenol caused a significant increase in LH level where other hormones remained unchanged. In addition a significant reduction was found in AST, ALT and LDH level while alkaline phosphatase increased significantly following treatment with para-nonylphenol. There was no change in the level of lipids and proteins in this study with respect to para-nonylphenol treatment. Co-administration of wheat germ oil with para-nonylphenol compensated the imbalance of the LH, AST, ALT and LDH caused by para-nonylphenol to the control level. However treatment of the rats with only wheat germ oil caused a significant reduction in the level of the hormones except for progesterone. Administration of wheat germ oil in any case caused a reduction in triglyceride level. Co-administration of wheat germ oil with para-nonylphenol eliminated the effect of para-nonylphenol on LH hormone as well as enzymes. It seems that daily used of wheat germ oil may have some benefits to the para-nohnylphenol exposure, however more clinical studies are needed to find more information.
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