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Prevention of cognitive impairment in diabetic rats with oral magnesium sulfate

Author(s): Mansoori M | Parviz M | Keshavarz M | Soltani N | Gharibzadeh Sh

Journal: Tehran University Medical Journal
ISSN 1683-1764

Volume: 65;
Issue: Sup 1;
Start page: 1;
Date: 2007;
Original page

Keywords: memory | maze

Background: Diabetes mellitus is a common metabolic disorder accompanied with structural and functional changes in central and peripheral nervous system. Researches showed, memory disturbance were occurred in the course of diabetes. On the other hand, magnesium deficit has been described in diabetic patients. Some researches were showed that, appropriate magnesium supplementation can play a positive role in diabetic control.Methods: Locally produced male rats were used. Diabetes was induced with intravenous injection of 40 mg/kg streptozotosin. In treatment groups, the animals were received magnesium sulfate via drinking water (10 g/l). Eight weeks after diabetes confirmation, the animals were assessed on Morris Water Maze.Results: A significant decrease in time of platform finding (latency) and distance of swimming in all four experimental days were seen in all groups. Mean latency in diabetic group was significantly higher than the other. This weak response was almost completely prevented by magnesium sulfate administration.Conclusion: It seems that after eight weeks magnesium sulfate administration (10g/l), spatial memory of the animals was improved in comparison to diabetic group that can suggest role of magnesium in recovery of diabetic animal memory.
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