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Prevention and management of non-steroidal anti-inflammatory drugs-induced small intestinal injury

Author(s): Sung Chul Park | Hoon Jai Chun | Chang Don Kang | Donggeun Sul

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 17;
Issue: 42;
Start page: 4647;
Date: 2011;
Original page

Keywords: Non-steroidal anti-inflammatory drugs | Small intestinal injury | Prevention | Treatment

Non-steroidal anti-inflammatory drug (NSAID)-induced small bowel injury is a topic that deserves attention since the advent of capsule endoscopy and balloon enteroscopy. NSAID enteropathy is common and is mostly asymptomatic. However, massive bleeding, stricture, or perforation may occur. The pathogenesis of small intestine injury by NSAIDs is complex and different from that of the upper gastrointestinal tract. No drug has yet been developed that can completely prevent or treat NSAID enteropathy. Therefore, a long-term randomized study in chronic NSAID users is needed.
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