Author(s): Piotr Radwan | Karolina Radwan-Kwiatek | Barbara Skrzydlo-Radomanska
Journal: Polish Gastroenterology
ISSN 1232-9886
Volume: 14;
Issue: 2;
Start page: 135;
Date: 2007;
Original page
ABSTRACT
Post-operative recurrence in Crohn's disease (CD) observed in endoscopy, manifested by clinical symptoms and sometimes requiring repeted surgery, is a difficult, unresolved therapeutic problem. Smoking, preoperative activity, multiple bowel involvement, ileocolic localization, perforating behaviour of the disease are clinical risk factors that seem to predispose to recurrence. Mesalazine is only mildly protective in patients with isolated small bowel disease. Immunosuppressants are effective in the prevention of postoperative relapse of CD, but few up-to-date studies are available in the literature. Nitroimidazole antibiotics prevent endoscopic and clinical recurrence, but they are not well tolerated. Budesonid and probiotics are not effective in the prophylactic treatment of post-operative recurrence of CD.
Journal: Polish Gastroenterology
ISSN 1232-9886
Volume: 14;
Issue: 2;
Start page: 135;
Date: 2007;
Original page
ABSTRACT
Post-operative recurrence in Crohn's disease (CD) observed in endoscopy, manifested by clinical symptoms and sometimes requiring repeted surgery, is a difficult, unresolved therapeutic problem. Smoking, preoperative activity, multiple bowel involvement, ileocolic localization, perforating behaviour of the disease are clinical risk factors that seem to predispose to recurrence. Mesalazine is only mildly protective in patients with isolated small bowel disease. Immunosuppressants are effective in the prevention of postoperative relapse of CD, but few up-to-date studies are available in the literature. Nitroimidazole antibiotics prevent endoscopic and clinical recurrence, but they are not well tolerated. Budesonid and probiotics are not effective in the prophylactic treatment of post-operative recurrence of CD.
