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Preventive and therapeutic effects of Bushen Huoxue Recipe on autoimmune premature ovarian failure in mice

Author(s): Li DONG

Journal: Zhong Xi Yi Jie He Xue Bao
ISSN 1672-1977

Volume: 6;
Issue: 3;
Start page: 294;
Date: 2008;
Original page

Keywords: ovarian failure | premature | herbal preparations | mice

Objective: To investigate the preventive effect of Bushen Huoxue Recipe (BSHXR), a compound traditional Chinese herbal medicine, on autoimmune premature ovarian failure (POF) in mice.Methods: Ovarian antigen was prepared with the ovarian tissue of female BALB/c mice. A mouse model of POF was established by immunization injection of the ovarian antigen of isotype female mice on multiple subcutaneous sites and two posterior soles. The POF mice were treated with BSHXR after the first and third immunization. The levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) in peripheral blood were detected by enzyme linked immunosorbent assay.Results: Lymphocyte infiltration was appeared in ovarian stroma of POF mice. The levels of FSH and LH were evaluated and the E2 level was decreased significantly (P
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