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Primary signet ring cell carcinoma of the appendix: A rare case report and our 18-year experience

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Author(s): Yoon Ho Ko, Chan-Kwon Jung, Soon Nam Oh, Tae Hee Kim, Hye Sung Won, Jin Hyoung Kang, Hyung Jin Kim, Won Kyung Kang, Seong Taek Oh, Young Seon Hong

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 14;
Issue: 37;
Start page: 5763;
Date: 2008;
Original page

Keywords: Appendiceal neoplasms | Carcinoma | Signet ring cell | Chemotherapy

ABSTRACT
Primary adenocarcinoma of the appendix is a rare malignancy that constitutes < 0.5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carcinoma of the appendix is an exceedingly rare entity. We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appendectomy over the past 18 years. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient. She underwent appendectomy and bilateral salpingo-oophorectomy with a laparoscopy procedure. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX-4). The patient currently is well without progression of disease 12 mo after beginning chemotherapy.
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