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Principais genes que participam da formação de tumores

Author(s): Aline A Lopes | Andreza M.Oliveira | Camila B. C. Prado

Journal: Revista de Biologia e Ciências da Terra
ISSN 1519-5228

Volume: 2;
Issue: 2;
Date: 2002;
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Keywords: Oncogens | anti-oncogens | cancer | gens suppresors

Anti-oncogens and oncogens, gens that participate of the formation of tumors. Anti-oncogens or gens suppresors of tumors is recessivos, that is, the cancer effect only appears when they are absent or are defective in the two chromosomes of the genoma, in contrast oncogens is dominant, and these codify proteins and promote the multiplication disordered of the cells, that if convert into malignant. A copy of oncogen in the genoma to cause the transformation of the normal cell in cancerous cell is enough. The main segments of DNA that participate of the appearance of tumors are anti-oncogens and oncogens, being that the first ones codify proteins that keep the G-zero cells and, therefore, is of the cellular cycle. As example we can cite gene RD, p53, p16, BRCA1, BRCA2, APC and VHL. Oncogens is derived from normal gens called proto-oncogen, that it takes the cell to lose the control on the mitótico cycle, dividing itself continuously. Amongst oncogens, ones of the most studied ras is oncogen, with its variants H-ras, K-ras and N-ras. Therefore the factors are several that take the individual to contract a cancer, and the previous diagnosis of the illness and eradication must soon be made in the start, making possible to save the life of the sick person.
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