Academic Journals Database
Disseminating quality controlled scientific knowledge

PROCESS DEVELOPMENT AND SCALE-UP OF FLUID-BED GRANULATION PROCESS

ADD TO MY LIST
 
Author(s): Dr.R.P.Ezhilmuthu

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 3;
Issue: 1;
Start page: 45;
Date: 2011;
Original page

Keywords: Fluid bed granulation | Scale - up | Process variables

ABSTRACT
Fluid-bed granulation studies were conducted to better understand the complexity of the process. Recently emerging innovative technologies are being developed to improve the Fluid-bed granulation process, process control and process robustness. In many cases the process development, scale-up and critical to quality of fluid bed granulation could be challenging and somewhat formulation-dependent. Granulation process are applied to improve flowability, improve compressibility, improve uniformity, improve wettability, densification and easier to disperse or transfer. Proper selection of equipment design, operating conditions and suitable excipients, Fluid-bed granulation technology can be scaled-up from the laboratory to commercial production successfully.
Save time & money - Smart Internet Solutions      Why do you need a reservation system?