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Prognosis of clinical course of squamous cell carcinoma of the larynx on the basis of establishing tumor’s immu-nohistochemical profile.

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Author(s): Gritsenko P.O.

Journal: Морфологія
ISSN 1997-9665

Volume: 1;
Issue: 4;
Start page: 21;
Date: 2007;
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Keywords: squamous cell carcinoma of the larynx | immunohistochemical markers | proliferation index | oncoprotein p53 | oncoprotein bcl-2 | cytokeratins

ABSTRACT
The work is dedicated to the study of expression of molecular markers in squamous cell carcinomas of the larynx in order to improve the diagnostics and to predict clinical course of the disease. Expression of cytokeratins СК34βЕ12 and СК19, oncoproteins p53 and bcl-2, proliferation index (basing on Ki-67 expression) were studied in tumors of different grades in patients with presence or absence of metastases, recurrent tumor, and different responses to chemoradiotherapy. Each marker’s value in diagnostics and prognosis was studied. Particular immunophenotypes which correspond with tumors of high risk of metastasis development (recurrence, possible sensitivity for chemo- and radiotherapy) were established for each tumor. A panel of markers that can be utilized to predict the possibility of metastases development within the first year after radical treatment (oncoproteins p53 and bcl-2 expression), to predict the response to chemo- (absence of p53) and radiotreatment (absence of bcl-2, high proliferation index) was suggested. Received data allows predicting laryngeal cancer’s clinical course, the possibility of metastases development and possibility of tumor’s recurrence, according to its immunohistochemical profile. This study enables to form clinical groups of patients which require more thorough clinical examination and supervision, more continuous and massive therapy, and also groups of patients, in which organ-saving methods of treatment may be applied.
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