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Prognostic significance of smac/DIABLO in endometrioid endometrial cancer.

Author(s): Bozena Dobrzycka | Slawomir J Terlikowski | Piotr S Bernaczyk | Magdalena Garbowicz | Jacek Niklinski | Lech Chyczewski | Marek Kulikowski

Journal: Folia Histochemica et Cytobiologica
ISSN 0239-8508

Volume: 48;
Issue: 4;
Start page: 678;
Date: 2011;
Original page

Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrial pathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examined smac/DIABLO expression in 76 patients with endometrioid endometrial cancers. Presence of smac/DIABLO was quantified by Western blot analysis using nonfixed fresh frozen tissues. Its appearance was found in 55 (72%) of examined tumors. Smac/DIABLO expression significantly correlated with tumor grade (p
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