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Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis

Author(s): Salih Cesur | Ali Şengül | Yasemin Kurtoğlu | Yasin Kalpakçı | Selcan Arslan Özel | Aybars Bilgetürk | Hakan Erdem | Turan Aslan | Sami Kınıklı | Can Polat Eyigün | Zeynep Bıyıklı

Journal: Journal of Microbiology and Infectious Diseases
ISSN 2146-3158

Volume: 1;
Issue: 3;
Start page: 101;
Date: 2011;
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Keywords: Sepsis | cytokines | CRP | prognosis

Objectives: The purpose of this trial was to investigate in patients with sepsis, the correlation between prognosis ofdisease and factors, which influence prognosis like gender, focus of infection, bacterial growth in blood culture, growingpathogens in addition to serum levels of cytokines (TNF-α, IL-10, leptin) and C-reactive protein.Material and methods: Forty-six adult patients with sepsis and 55 healthy adults as control group were enrolled in thisstudy. Serum cytokine (TNF-α, IL-10 and leptin) levels were determined by ELISA method and C-reactive protein (CRP)levels were measured by nephelometric method. Serum cytokine and CRP levels on day 0 (initial), day 3 and day 5 werecompared in surviving sepsis patients and patients who died because of sepsis.Results: Serum IL-10 level on day 0 (initial) of adult patients who died as a result of sepsis was found to be higher thansurviving patients and the difference was statistically significant (p=0.025). On 3rd day of treatment, serum TNF-α andCRP levels of patients who dies because of sepsis were higher than values of surviving patients (for TNF-α p=0.033, forCRP p=0.026). In adult patient group with sepsis who died on the 5th day of treatment, serum TNF-α level was significantlyhigher than levels in surviving patients (p=0.030).Conclusion: It was determined that in patients who died due to sepsis, initial serum IL-10 level, TNF- α and CRP levelson 3rd day of treatment and finally on 5th day of treatment, only serum TNF- α level was higher than surviving patients.We believe that determining serum TNF-α and IL-10 levels in patients with sepsis before and during treatment will helpclinicians to clarify prognosis and enable them to implement appropriate treatment modifications. J Microbiol Infect Dis2011; 1(3):101-109
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