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Proliferative activity of Guerin’s tumour cells under the action of homologic tumour rhibonucleic acids

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Author(s): Khripkov I.S.

Journal: Морфологія
ISSN 1997-9665

Volume: 2;
Issue: 3;
Start page: 77;
Date: 2008;
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Keywords: Proliferative activity | exogenous RNA | Guerin’s carcinoma

ABSTRACT
Ability of exogenous rhibonucleic acids (RNAs) to penetrate into cells and to cause the phenotypic transformations, changing the character of metabolic process, was the reason for application of RNAs with the purpose of determined action on metabolism of tumour cells. The aim of our research was to study the influence of homologic tumour RNAs on proliferative activity of Guerin’s carcinoma cell. We used the transplantable tumor culture of Guerin’s carcinoma. RNAs was extracted by the method of thermal phenol fractioning. Radiolabeled nuclei index decreased for 40% after exogenous homological tumour RNAs treatment. It was accompanied by the decrease of packing tissues index for 15%. Thus, on the basis of analysis of experimental material we can conclude that exogenous homological tumour RNAs causes the decrease of DNA-producing cells number with the increase of atipism degree of Guerin’s carcinoma cells.
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