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Prolongation of the QTc interval in patients with cirrhosis

Author(s): K. Mimidis, V. Papadopoulos, K. Thomopoulos, D. Tziakas, K. Ritis, V. Dalla, S. Kotsiou, | V. Nikolopoulou, D. Hatseras, G. Kartalis

Journal: Annals of Gastroenterology
ISSN 1108-7471

Volume: 16;
Issue: 2;
Date: 2007;
Original page

SUMMARY QT interval prolongation predicts severe ventricular arrhythmias and sudden death. The aim of this work was to confirm the prevalence of QT interval prolongation in patients with liver cirrhosis due to alcoholism and chronic hepatitis B or C and define its association with the severity of the disease. Fifty-two patients with cirrhosis (29 due to alcohol abuse and 23 due to chronic hepatitis B or C) were enrolled. In all patients QT interval corrected (QTc) for ventricular heart rate was assessed along with Child-Pugh score. QTc was found prolonged in both groups of patients with alcoholic and postviral cirrhosis (0,471 sec, P=0,0007 and 0,461 sec, P=0,0017 respectively) with no difference between the two groups (P=0,3142). Prolongation of the QTc interval was statistically confirmed in Child-Pugh C and B groups (0,489 sec, P=0,0019 and 0,480 sec, P=0,0002 respectively) but not in Child-Pugh A group (0,445 sec, P=0,4366). These data show that QTc interval prolongation in cirrhotic patients refers to Child-Pugh B and C but is independent from the etiology of cirrhosis. Key words: QT interval, cirrhosis, alcoholism, chronic hepatitis, hepatitis B, hepatitis C.
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