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A PROSPECTIVE, OBSERVATIONAL COHORT STUDY TO ELICIT ADVERSE EFFECTS OF ANTI-TUBERCULOSIS DRUGS AMONG PATIENT TREATED FOR ACTIVE TUBERCULOSIS

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Author(s): Sourav Ghosh

Journal: Pharma Research
ISSN 0975-8216

Volume: 03;
Issue: 01;
Start page: 10;
Date: 2010;
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Keywords: Tuberculosis | Adverse Effect | Side Effect | Anti-Tuberculosis Drug

ABSTRACT
Tuberculosis is one of the foremost public health problems causing an enormous problem of suffering and death. Chemotherapy is the basic approach to clinical tuberculosis control. Essential anti-tuberculosis drugs are Isoniazid (INH), Rifampicin (RMP), Pyrazinamide (PZA), Ethambutol (E) and Streptomycin(S). The study was conducted on the tuberculosis patients of Mathura Hospital (U.P) during March 2009 to February 2010. Total 212 newly diagnosed pulmonary and extra pulmonary tuberculosis patients were included in the present study. Patients were kept under observation during whole treatment period. Clinical biochemical monitoring from the basis of diagnosing side effect due to anti-tuberculosis therapy. Among the 212 cases studied, 66.04% were male and 33.96% were female. The symptom based common minor side effects of anti-tuberculosis drugs were nausea, vomiting, anorexia, diarrhoea (41.98%, 10.36%, 12.74%, and 2.36% respectively). Of the 212 patients treated for tuberculosis, 43 patients (20.28%) had major side effects. Among them, 15 patients (7.08%) experienced jaundice, 21 patients (9.90%) experienced flu syndrome and seven patients (3.30%) experienced skin rash. In this study showed that male with above 35 years of age of the patients are more prone to major adverse effect.
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