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Prospects for the Use of ATR Inhibitors to Treat Cancer

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Author(s): Jill M. Wagner | Scott H. Kaufmann

Journal: Pharmaceuticals
ISSN 1424-8247

Volume: 3;
Issue: 5;
Start page: 1311;
Date: 2010;
Original page

Keywords: Replication checkpoint | ATR | ATM | chemotherapy | Chk1

ABSTRACT
ATR is an apical kinase in one of the DNA-damage induced checkpoint pathways. Despite the development of inhibitors of kinases structurally related to ATR, as well as inhibitors of the ATR substrate Chk1, no ATR inhibitors have yet been developed. Here we review the effects of ATR downregulation in cancer cells and discuss the potential for development of ATR inhibitors for clinical use.
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