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Prostaglandins, Histamine and Platelet Activating Factor: Different Mediators in Dithranol-Induced Skin Damage

Author(s): Hamidreza Pazoki-Toroudi | Nahid Abotaleb | Morteza Tavakkoli Hoseini | Yahya Dowlati

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 2;
Issue: 2;
Start page: 35;
Date: 2003;
Original page

Keywords: Dithranol | Prostaglandin | Histamine | Platelet activating factor | Garlic

Dithranol is a potent agent in treating psoriasis but its adverse effects on intact skin have limited its usage. There are many proposed mediators for its adverse effects including prostaglandins, histamine, platelet activating factor and free radicals. In this study we examined the effect of different agents (diazepam, terfenadine, indomethacin and garlic extract) on dithranol-induced skin damage in mice. Animals were treated with different drugs before local application of dithranol cream on the right buttock. Skin biopsy was performed after 48 or 96 hours. Diazepam (3 mg/Kg), terfenadine (20 mg/Kg), indomethacin (25 mg/Kg) and garlic extract (1% and 2%) were all capable of reducing dithranol-induced skin damage. It seems that the role of prostaglandins, histamine and platelet activating factor in the pathogenesis of dithranol-induced skin damage is inevitable. Garlic extract effect might be mediated by platelet activating factor but it needs further work to be proven.
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