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Protection of renal tubules against gentamicin induced nephrotoxicity

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Author(s): Tavafi Majid

Journal: Journal of Renal Injury Prevention
ISSN 2345-2781

Volume: 2;
Issue: 1;
Start page: 5;
Date: 2013;
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Keywords: Gentamicin | Nephrotoxicity | Metformin | Garlic | Antioxidants

ABSTRACT
Implication for health policy/practice/research/medical education:It seems that renal tubular damages in acute renal failure involved in gentamicin nephrotoxicity or ischemia/reperfusion mainly induced by increasing of reactive oxygen species (oxidative stress). According to this attitude, many researchers have been used different antioxidant agents in combat with gentamicin nephrotoxicity. Treatment of animal with metformin against gentamicin revealed that gentamicin might be induced renal tubular damages via energy depletion in renal tubular cells besides inducing of oxidative stress. More studies are needed to clarify renal protective effect of adenosine monophosphate-activated protein kinase (AMPK) activator such as metformin in combat with gentamicin nephrotoxicity.
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