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PROTECTIVE ABILITY OF MOMORDICA CHARANTIA L AGAINST CCL4 INDUCED HEPATIC DAMAGE IN RATS

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Author(s): Pingale Shirish S

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 1;
Issue: 2;
Start page: 433;
Date: 2010;
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Keywords: Momordica charantia | hepatoprotective | AST | ALT | Silymarin

ABSTRACT
The aim of this study is to evaluate the efficacy of Momordica charantia on the experimental hepatotoxicity induced by carbon tetrachloride (CCl4). Carbon tetrachloride was administered once and simultaneously suspension of dry fruit powder was prepared in aqueous medium and was daily administered at a dose level of 1mg/kg body weight for 4 days. Silymarin was used as a standard drug for this study. Administration of carbon tetrachloride showed significant changes in the levels of serum aminotransferase, alkaline phosphatase, bilirubin and total proteins levels, however necrosis, collagen deposition and altered hepatic architecture were also observed. Markers of liver injury, altered aminotransferase, alkaline phosphatase, bilirubin etc. and morphological changes such as necrosis and collagen deposition were significantly decreased in the rats treated with Momordica charantia fruit powder. These results suggest that the Momordica charantia showed hepatoprotective effect on carbon tetrachloride induced hepatic damage and may be a potential clinical application for treatment of liver diseases.
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