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Protective Activity in Paracetamol Induced Hepatotoxicity and Antioxidant Potential from Lippia nodiflora (Verbenaceae) in Rats

Author(s): Ashokkumar Durairaj | Thamil Selvan Vaiyapuri | Mazumder Upal Kanti | Gupta Malaya

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 7;
Issue: 1;
Start page: 83;
Date: 2008;
Original page

Keywords: Antioxidant estimation | Biochemical analysis | Hepatoprotective | Hepatotoxicity | Lippia nodi- flora | Paracetamol | Rats

This study was designed to evaluate the hepatoprotective and antioxidant activity of methanol extract of Lippia nodiflora (MELN) in acute experimental liver injury induced by paracetamol (750mg/kg, b.w). MELN at the doses of 200 and 400mg/kg, p.o was administered for 7 days and biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin and total proteins with enzymatic and non-enzymatic antioxidant level were recorded. MELN at both doses prevented the increase in liver weight when compared to hepatotoxin treated control. The higher dose (400 mg/kg) of Lippia nodiflora extract was found to be more effective than the lower dose (200 mg/kg) in paracetamol induced liver damage. MELN produced significant (p

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