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Protective effect of 18b-glycyrrhetinic acid on lipid peroxidation and antioxidant enzymes in experimental diabetes

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Author(s): P. Kalaiarasi and K.V. Pugalendi

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 1;
Start page: 107;
Date: 2011;
Original page

Keywords: Lipid peroxidation | antioxidants | 18ß-glycyrrhetinic acid | diabetes

ABSTRACT
Chronic hyperglycemia in diabetes is a major causative factor of free radical generation, which further leads to many secondary diabetic complications via the damage to cellular proteins, membrane lipids, nucleic acids and eventually to cell death. Recently we reported the antidiabetic effect of 18ß-glycyrrhetinic acid on diabetic rats. This study was focused on the protective effect of 18ß-glycyrrhetinic acid on lipid peroxidation, activities of both enzymatic and non-enzymaticantioxidants and histopathological examination of pancreas in diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, weighing 180–200 g, by administration of streptozotocin (40 mg/kg of body weight) intraperitoneally. The oxidative stress was measured by plasma and tissue lipidperoxidativemarker (thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes) levels, non-enzymatic antioxidants (reduced glutathione, vitamin C and vitamin E) and enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase and Glutathione-S-transferase) activities. The increased lipidperoxidation level with reduction in reduced glutathione, vitamin C and vitamin E and decreased enzymatic activities were the salient features observed in diabetic rats. On the other hand, oral administration of 18ß-glycyrrhetinic acid (100 mg/kg day) for 45 days, resulted in a significant reduction in lipid peroxidation levelcoupled with increased activities of both enzymatic and non-enzymatic antioxidants when compared to diabetic rats. Administration of 18ß-glycyrrhetinic acid in diabetic rats minimized the changes and near normal morphology of pancreas was observed in histopathological examination. 18ß-glycyrrhetinic acid is having a good antioxidant property, as evidenced by increased antioxidants status and decreased lipid peroxidation, which reflects the protective effect of 18ßglycyrrhetinic acid from the risk of diabetic complications.

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