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Protective effect of Curcuma longa extract on acetaminophen induced nephrotoxicity in mice

Journal: DARU : Journal of Pharmaceutical Sciences
ISSN 1560-8115

Volume: 16;
Issue: 3;
Start page: 155;
Date: 2008;
Original page

Background and purpose of the study: Acetaminophen is a commonly used analgesic and antipyretic agent which, in high doses, causes liver and kidney necrosis in man and animals. Curcuma longa has been reported to have anti oxidant and hepato-protective properties. In this study the protective effect of Curcuma longa extract on acetaminophen induced nephrotoxicity has been evaluated. Materials and methods: Sixty NMRI male mause were randomly divided into 6 groups. Control group received normal saline.  Curcuma longa group received 1000 mg/kg of the extract of the plants, positive control group received 500 mg/kg acetaminophen. Acetaminophen and Curcuma longa extract at doses of 400, 800 and 1000 mg/kg were administered to the tested groups (T1- T3) at the same time. The jugular arteries of the mice were cut for biochemical testes after 48 hours and the kidney removed in 10% formalin solution for histopathology testes.  Results: BUN, Cr and Uric acid reduced significantly in the T3 group (p
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