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PROTECTIVE EFFECT OF NERIUM INDICUM ON CCl4 INDUCED HEPATOTOXICITY IN RATS

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Author(s): Govind Patel

Journal: International Journal of Biomedical Research
ISSN 0976-9633

Volume: 1;
Issue: 4;
Start page: 147;
Date: 2011;
Original page

Keywords: Nerium indicum | Hepatoprotective activity | carbon tetrachloride

ABSTRACT
Methanolic flowers extract of Nerium indicum was evaluated for hepatoprotective in rats. The plant extract (500 and 1000 mg/kg, p.o.) showed a remarkable hepatoprotective activity against carbon tetrachloride induced hepatotoxicity in liver tissues. Carbon tetrachloride induced a significant rise in Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT) and alkaline phosphatase (ALP). Treatment of rats with different doses of plant extract (500 and 1000 mg/kg) significantly (P
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