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Protective effect of Ocimum sanctum on lipid peroxidation, nucleic acids and protein against restraint stress in male albino rats

Author(s): I Tabassum | ZN Siddiqui | SJ Rizvi

Journal: Biology and Medicine
ISSN 0974-8369

Volume: 1;
Issue: 2;
Start page: 42;
Date: 2009;
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Keywords: Ocimum sanctum | restraint stress | nucleic acids | lipid peroxidation | brain

Effect of restraint stress on brain oxidative stress parameters and their modulation by Ocimum sanctum Linn(OS) were evaluated in male albino rats. Rats were subjected to restraint / immobilization stress 3h/day for 6consecutive days. Post administration of aqueous extract of OS (100 mg/kg for 6 consecutive days) wasgiven following restraint stress. MDA a marker of lipid peroxidation, nucleic acids and proteins wereestimated in cerebrum, cerebellum and brain stem. Exposure to restraint stress caused a significantelevation in the rate of lipid peroxidation, reduction in nucleic acids and proteins as compared to control in allthree regions of brain of male albino rats. Post treatment of aqueous extract of OS prevented the stressinduced changes in these biochemical parameters. The results of the study indicate the protective nature ofOS on different regions of brain against the detrimental effect of restraint stress.

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