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PROTECTIVE EFFECT OF TAHITIAN NONI JUICE ON THE REPRODUCTIVE FUNCTIONS OF MALE WISTAR RATS TREATED WITH CYCLOPHOSPHAMIDE

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Author(s): AJADI ADETOLA ABIDEMI

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 10;
Issue: 1;
Date: 2011;

ABSTRACT
Aim: To compare the effect of Tahitian noni juice (TNJ), vitamin C or vitamin E on male reproductive functions in wistar rats treated with cyclophosphamide. Methods: Thirty five male wistar rats with mean body weight (180 ± 24.3g) were randomly divided into five groups. Group one rats were treated with cyclophosphamide (50mg/kg, IP) while, group two rats were treated with TNJ (10ml/kg) and cyclophosphamide. Group three rats were treated with TNJ (10ml/kg) alone. Group four and five rats were treated with cyclophosphamide and either of vitamin C (100mg/kg) or E (1mg/kg) respectively. All drugs were administered for four weeks. In this study, mean weight gain, sperm motility (SM), live- dead ratio (LDR), epididymal sperm counts (ESC), percentage sperm abnormality, as well as, testicular histological changes were determined. Data were expressed as mean ± standard deviation. The ESC, SM and LDR were compared with analysis of variance (ANOVA). Median score for the histologic changes was analyzed using Wilcoxon sign rank test. Results: The mean weight gain was higher in Groups 2 and 3 compared with other groups (P < 0.05). Similarly, the SM was higher in rats treated with TNJ compared with other groups (P < 0.001). The LDR, ESC, and testicular histologic scores did not differ between the five groups of rats. However, the percentage sperm abnormality was lower in groups 2 and 3 (P
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