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The protective effects of Saffron against the oxidative damage in a transient model of focal cerebral ischemia in rats

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Author(s): Vakili A | Eianali MR | Bandegi AR

Journal: Tehran University Medical Journal
ISSN 1683-1764

Volume: 69;
Issue: 7;
Start page: 405;
Date: 2011;
Original page

Keywords: Brain edema | focal cerebral ischemia | oxidative damage | rat | saffron

ABSTRACT
"nBackground: Numerous studies have shown the protective effects of saffron against oxidative damage in a global model of cerebral ischemia, but its effects on brain edema and oxidative ischemic injury in focal ischemic stroke are not completely understood. Therefore, this study was designed to investigate the effects of saffron on brain edema, infarct volume, antioxidant enzyme activity (glutathione peroxidase and superoxide dismutase) and concentration of malondialdehyde (MDA) in ischemic brain tissue in an experimental model of stroke."n "nMethods: Focal brain ischemia was established with the temporary occlusion of the middle cerebral artery for one hour in rats. Saffron (100 mg/kg) was given intra-peritoneally at the onset of ischemia. 24 hours later, brain edema and infarct volume were evaluated and glutathione peroxidase and superoxide dismutase activities and MDA concentration were measured in the ischemic brain tissue using a specific kit."n "nResults: The results showed that saffron reduced infarct volume by 77% (P
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