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The Protective Nature of Garlic, Ginger and Vitamin E on CCl4-Induced Hepatotoxicity in Rats

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Author(s): K.C. Patrick-Iwuanyanwu | M.O. Wegwu | E.O. Ayalogu

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 2;
Issue: 6;
Start page: 409;
Date: 2007;
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Keywords: Carbon tetrachloride | haematological parameters | garlic | ginger | vitamin E

ABSTRACT
4-induced liver damage in rats were investigated using selected haematological indices: PCV, Hb, WBC, polymorphonuclear cells and lymphocytes. PCV was lowest in rats administered garlic-ginger (1:2) and CCl4 (0.5 mL kg-1 bw) with a mean value of 28.7%. However, highest PCV values were obtained in rats that were given rat pellets alone without CCl4.Hb of rats pre-treated with vitamin E recorded the lowest mean value while rats treated with garlic and ginger (2:1) only, recorded the highest mean value of 101.2 g dL-1). Hb levels were increased in rats pre-treated with ginger, garlic and ginger (1:1), garlic and ginger (1:2). CCl4 treatment caused an elevation of WBC in rats pre-treated with garlic, ginger, vitamin E and mixtures of garlic and ginger. This increase was observed to be highest in rats treated with a mixture of CCl4, garlic and ginger (1:2) (10860 mm-3 L-1). However, rats in the group treated with feed only without CCl4 recorded the lowest WBC. Among the groups injected with CCl4, a lower WBC value of 6200 mm-3 L-1 was recorded in the group fed vitamin E. These findings suggest that the pre-treatment of rats with mixtures of garlic and ginger prior to CCl4-administration would result in an increase in the PCV and Hb values and a decrease in WBC values.]]>
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