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Protective Response of Dried Stems of Cassia auriculata against Carbon Tetrachloride induced Liver Damage in Wistar Albino Rats

Author(s): P. Swathi | T. Jagadeesh Kumar | M. Madhu Babu | Ch. Vijay

Journal: International Journal of Advances in Pharmaceutical Sciences
ISSN 0976-1055

Volume: 1;
Issue: 3;
Date: 2011;
Original page

Keywords: Cassia auriculata | hepatoprotective activity | silymarin | CCl4

Chronic liver diseases commonly result in liver fibrosis. Carbon tetra chloride (CCl4) is widely used for experimental induction of liver fibrosis. It is a potent heptotoxin producing centrilobular necrosis which causes liver injury. Five groups of 3 rats each were used. First group (normal control) was given 1 ml of liquid paraffin /kg b.wt. Daily for 21 days and kept as normal control. Rats of the second group were given the same dose of liquid paraffin, in addition CCl4 (30% in liquid paraffin) was given in a single oral dose of 1 ml /kg b.wt, for every 72 hours. Rats of the third, fourth and fifth groups were pre-treated orally with 25 mg/kg b.wt of silymarin, 200 and 400 mg/kg of ethanolic extract of cassia auriculata suspended in 1% CMC. Serum was separated and used for various biochemical estimations. Liver and kidney were collected in ice-cold containers, washed with saline, homogenized with appropriate buffer and used for the estimation of protein, liver enzymes (SGPT & SGOT), ALP, hepatic TBARS and glutathione. The experiment was carried out to investigate the role of antioxidant enzymes and liver enzymes such GSH, LPO, ALP, SGOT, SGPT & protein. This protective effect of this drug can be correlated directly to its antioxidant and hepatoprotective property.Keywords: Cassia auriculata, hepatoprotective activity, silymarin, CCl4
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