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Protective Response of Methanolic Extract of Ocimum sanctum,Withania somnifera and Zingiber officinalis on Swimming-Induced Oxidative Damage on Cardiac, Skeletal and Brain Tissues in Male Rat: a Duration Dependent Study

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Author(s): Debanka Sekhar Misra | Rajkumar Maiti | Chhanda Mallick | Debidas Ghosh

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 2;
Issue: 6;
Start page: 647;
Date: 2006;
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Keywords: Forced swimming | oxidative stress | brain tissues | cardiac and skeletal muscles | antioxidant | phytotherapy

ABSTRACT
The present study focused the duration dependent protective effects of methanolic extract of root of Withania somnifera, leaf of Ocimum sanctum and rhizome of Zingiber officinalis in composite way on severe exercise-induced oxidative damage in cerebrum, cerebellum, cardiac and skeletal muscles. Results indicate that catalase and superoxide dismutase activities were decreased alongwith increase in the levels of thiobarbituric acid reactive substances and conjugated dienes in aforesaid tissues significantly in forced swimming group which were protected significantly in a graded manner after 14 days supplementation or 28 days co-administration of composite extract and in some cases only after last 7 days of the said extract supplementation. Complete protection was noted when co-administration and swimming periods were same like 28 days time profile but such complete recovery in above parameters was not observed when supplementation was continued for last 7 or 14 days out of 28 days of swimming. The above extract has no general toxic effect reflected here from the study of body weight and transaminase activities in liver and kidney. The results convey the message that above extract has a significant corrective effect on swimming-induced oxidative damage on vital tissues and for which a minimum period of such extract supplementation or co-administration is essential.
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