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Protective role of antioxidant vitamin E and catechin on idarubicin-induced cardiotoxicity in rats

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Author(s): Kalender S. | Kalender Y. | Ates A. | Yel M. | Olcay E. | Candan S.

Journal: Brazilian Journal of Medical and Biological Research
ISSN 0100-879X

Volume: 35;
Issue: 11;
Start page: 1379;
Date: 2002;
Original page

Keywords: Idarubicin | Catechin | Vitamin E | Cardiotoxicity | Ultrastructure

ABSTRACT
Idarubicin is an anthracycline antibiotic extensively used in acute leukemia. In the present study we investigated whether vitamin E and catechin can reduce the toxic effects of idarubicin. Vitamin E (200 IU kg-1 week-1), catechin (200 mg kg-1 week-1), idarubicin (5 mg kg-1 week-1), idarubicin + vitamin E (200 IU kg-1 week-1), and idarubicin + catechin (200 mg kg-1 week-1) combinations were given to male Sprague-Dawley rats weighing 210 to 230 g (N = 6/group). Idarubicin-treated animals exhibited a decrease in body and heart weight, a decrease in myocardial contractility, and changes in ECG parameters (P
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