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PROTECTIVE ROLE OF GLUTATHIONE IN TUNGSTEN-INDUCED TOXICITY IN BLOOD COMPONENTS: A PHARMACOLOGICAL AND TOXICOLOGICAL PERSPECTIVE

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Author(s): Arshad Farid | Abdul Haleem Shah | Muhammad Mukhtiar

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 3;
Start page: 943;
Date: 2011;
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Keywords: Reduced Glutathione (GSH) | Sodium Tungsten (ST) | 5 | 5-Dithiobis | 2- nitro benzoic acid (DTNB) | venous blood and Ellman’s method.

ABSTRACT
Sodium tungstate (Na2WO4), a pharmacological agent lacks information on its molecular mechanism of action. Therefore it was of interest to examine the effect of Sodium tungstate (ST) on the metabolic status of glutathione (GSH) in plasma and cytosolic fraction of blood of healthy human volunteer. In the current study, the effect of Sodium Tungstate on the chemical and metabolic status of Glutathione in human venous blood components was carried out spectrophotometerically. Results showed that concentration of GSH lowered upon addition of ST to venous blood of volunteers. The lower content of GSH was found to be ST concentration and time dependent. The lower GSH content in venous blood components i.e. plasma and cytosolic fraction upon addition of ST may be either due to formation of ST-SG complex or conversion of reduced GSH to GSSG.
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