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PROTECTIVE ROLE OF NANOCONJUGATED VANCOMYCIN AGAINST VANCOMYCIN SENSITIVE STAPHYLOCOCCUS AUREUS INDUCED OXIDATIVE STRESS AND DNA DAMAGE

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Author(s): Somenath Roy et al.

Journal: International Journal of Pharmaceutical Sciences and Research
ISSN 0975-8232

Volume: 3;
Issue: 2;
Start page: 405;
Date: 2012;
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Keywords: VSSA | Nitrate generation | Lipid peroxidation | Antioxidant enzyme | DNA fragmentation

ABSTRACT
Staphylococcus aureus causes a wide range of infection such as skin and soft tissue infection to life threatening disease like respiratory tract infection, musculoskeletal infection, endocarditis and urinary tract infection. The aim of the present study was to evaluate the possible protective effects of nanoconjugated vancomycin against VSSA infection on select makers of oxidative damage and antioxidant status in liver, kidney and spleen. A coagulase positive VSSA strain was used for this study. VSSA infection was developed in Swiss mice by intraperitoneal injection of 5 X 106 CFU/ml bacterial solutions. Nanoconjugated vancomycin was treated to VSSA infected mice at a dose of 100 mg/kg b.w/day for 10 days. After decapitation, liver, kidney and spleen were excised from control and experimental groups, homogenized and used for different biochemical estimation. Nitrate level, myeloperoxidse activity, lipid peroxidation, protein oxidation, oxidized glutathione, DNA fragmentation level were increased significantly (p
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