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Protective Role of Water Extract of Unripe Pulp of Carica papaya (Fruit) Against a Potassium Bromate Induced Tissue Damage in Wistar Rats

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Author(s): S.J. Josiah | S.C.O. Nwangwu | A.A. Akintola | Abaja Vivian | G.O. Erifeta | A.A. Asuk | S.E. Uhunmwamgho

Journal: British Journal of Pharmacology and Toxicology
ISSN 2044-2459

Volume: 2;
Issue: 4;
Start page: 205;
Date: 2011;
Original page

Keywords: Carica papaya | free radicals | malondialdehyde | potassium bromate

ABSTRACT
The aim of this study was to evaluate the protective role of water extract of unripe pulp of Carica papya against potassium bromate induced tissue damage in wistar rats. Twenty (20) rats were grouped into five groups of four rats each. Group A (base-line control), was administered 1 mL of 0.25 M sucrose solution. Group B was not pretreated with the extract but induced with KBrO3. Group C and D were pretreated with 250 mg/kg and 500 mg/kg body weight of the extract respectively. Tissue damage was induced in Group B, C, and D by oral administration of 60mg/kg body weight of potassium bromate. The rats were sacrificed eight hours after KBrO3 induction and, the liver, spleen, brain, kidney, heart and stomach were collected. The organ to body weight ratio, total protein, amino acid and malondialdelhyde level were evaluated in the tissue. The result showed a significant increase (p
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