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PROTEIN OXIDATION AND ANTIOXIDANT VITAMINS IN LEPROSY

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Author(s): Sunita Girish

Journal: International Journal of Pharmaceutical Sciences and Research
ISSN 0975-8232

Volume: 2;
Issue: 11;
Start page: 2870;
Date: 2011;
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Keywords: Leprosy | Protein carbonyl | Antioxidant vitamins | Protein oxidation

ABSTRACT
Methods: Total 30 leprosy cases were studied. Patients were subjected to various tests like, serum protein carbonyl as an index of protein oxidation, while serum Vitamin C and Vitamin E levels as endogenous antioxidants.Aims The presence of carbonyl groups in proteins has been used as a marker of ROS-mediated protein oxidation. The present work was undertaken to study the importance of endogenous antioxidants like Vitamin C and vitamin E in different types of leprosy patients.Results: An increased level of protein carbonyl indicates oxidative stress .The levels of Vitamins C, E decreased significantly in leprosy.Conclusions: Protein carbonyl can be used as sensitive indicator of oxidative stress in leprosy patients. Vitamin C and vitamin E can be supplemented along with anti-leprosy drugs to control the protein oxidation in leprosy patients.

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