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Proteomics based prediction of antigenicity of iberiotoxin from eastern Indian scorpion

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Author(s): Gomase V.S. | Phadnis A.C. | Waghmare Somnath

Journal: International Journal of Drug Discovery
ISSN 0975-4423

Volume: 1;
Issue: 1;
Start page: 10;
Date: 2009;
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Keywords: iberiotoxin | Na+-channel | Antigenic epitope | GOR | Hydrophobicity | Hydrophilicity

ABSTRACT
Scorpion venom is an antigenic, water-soluble, heterogenous mixture. The Na+-channelspecific toxins from scorpions are modifiers of the channel gating mechanism. The recombinant DNAvaccines involved targeting multiple antigenic components to direct and empower the immune system toprotect the host from infection. Limitation of therapy to the treatment of patients suffering from variousadverse reaction and contraindications are always experienced. Antigenic epitope on iberiotoxin -eastern Indian scorpion are important determinant of protection against spider venom. As ourknowledge of the immune responses to a protein antigen progressed, it became clear that the wholeprotein is not necessary for raising the immune response, but small segments(DVDCSVSKECWSVCKDLFG; 4-22) of protein called the antigenic determinant or the epitope issufficient for eliciting the desired immune response. In analysis predicted antigenic epitope iberiotoxinprotein is seen. Antigenic epitope from iberiotoxin is a predicted immunization strategy against variousdiseases.

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