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Psoriasis and infestation with Malassezia

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Author(s): Z Javidi | Maleki | Fata | Nahidi | Esmaeili | Hosseini

Journal: Medical Journal of the Islamic Republic of Iran
ISSN 1016-1430

Volume: 21;
Issue: 1;
Start page: 11;
Date: 2007;
Original page

Keywords: psoriasis | malassezia | etiology

ABSTRACT
 Abstract Background: Psoriasis is a chronic proliferative condition of the skin. Its accurate pathogenesis has not been known yet, but interactions between genes and environmental factors have been implicated in its initiation. The role of malassezia in psoriasis is still undetermined, but several reports have associated these lipophilic yeasts with the development of skin lesions in psoriasis.Our aim was to investigate the correlation between malassezia and psoriasis. Methods: In this case control study over a 6 month period skin samples were obtained from lesions of 50 psoriatic and 50 healthy volunteers to evaluate malassezia infestation. Obtained data were collected by questionnaires and analyzed by SPSS software and applying statistical tests of χ2 and Mann-Whitney. Results: There was no difference between malassezia infestation in scalp lesions of psoriatic and control cases (P=0.86). Malassezia infestation in psoriatic patients with scalp involvement was more than those without it, but it was not a significant relationship (P=0.069). There was an inverse significant correlation between scalp infestation with malassezia and chronicity of psoriasis (P=0.04). This infestation in trunk skin of patients was less than normal individuals (P
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