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Author(s): Shah Murad

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 11;
Start page: 1;
Date: 2011;
Original page

Keywords: Atherosclerosis. Primary hyperlipidemia. Heart disease. Psyllium husk.Cholesterol.Triglycerides.

In this single blind placebo controlled research study we examine the effects of psyllium husk on lipid profile of primary hyperlipidemic patients. Research was conducted in Jinnah Hospital Karachi, Pakistan, from December 2008 to June 2009. Forty already diagnosed hyperlipidemic patients were included, in the study. Twenty patients were on placebo as control/compare group, and twenty were on psyllium husk, ten gram daily, in divided doses for the period of three months. Exclusion criteria was patients with hypothyroidism, alcoholism, renal and hepatic disease. Serum cholesterol and triglycerides were estimated by the enzymatic calorimetric method. Serum HDL-Cholesterol was determined by direct method, at day zero and at last day of the treatment. LDL-Cholesterol was calculated by Friedwald formula (LDL= Tc- (TG/5 + HDL-C). Data were expressed as the mean ± SD and “t” test was applied to determine statistical significance of results. P value lesser than 0.05 was the limit of significance. When results compiled it was observed that two patients discontinued to take drug given, due to metallic test of psyllium husk. Psyllium decreased serum total cholesterol from 228.27±4.89 mg/dl to 199.22 ± 2.30 mg/dl, triglycerides from 169.27± 9.92 mg/dl to 164.5±8.56 mg/dl, LDL-Cholesterol from 159.72 ± 5.70 to 129.55± 2.81 mg/dl, and increased serum HDL-Cholesterol from 34.61±1.85 to 36.77±1.96 mg/dl in three months of treatment. Results of all parameters were significant when paired ‘t’ test was applied for result analysis. At end of the research work we concluded that psyllium is very effective agent to maintain lipid profile parameters at normal limits in hyperlipidemic patients.
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