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Pulmonary mantle cell lymphoma: a rare manifestation of an uncommon condition

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Author(s): Zachary S. DePew | Robert Vassallo

Journal: Rare Tumors
ISSN 2036-3603

Volume: 4;
Issue: 1;
Start page: e11;
Date: 2012;
Original page

Keywords: pulmonary lymphoma | mantle cell lymphoma

ABSTRACT
Herein we describe the case of a 64-year old man with a history of mantle cell lymphoma found to have evidence of pulmonary parenchymal involvement by recurrence of his lymphoma. While lung involvement is not necessarily uncommon with Non-Hodgkin’s lymphomas as a group, it is very rare for mantle cell lymphoma to involve the lung parenchyma. In addition, the radiographic manifestation of his pulmonary lymphoma as a discrete FDG-avid ground-glass lesion on chest imaging was also distinctly uncommon for pulmonary lymphoma which classically appears in one of three patterns: scattered ill-defined nodules, a bronchovascular/lymphangitic process, or pneumonic/alveolar consolidation effectively indistinguishable from bacterial pneumonia. Due to significant underlying lung disease our patient was not a candidate for high-dose conditioning and autologous stem cell transplantation. He was ultimately treated with rituximab and cladribine therapy and had early signs of clinical response at last correspondence.

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