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QUANTITATIVE ANALYSIS OF DIFFERENT BRANDS OF DEXAMETHASONE TABLET MARKETED IN MAIDUGURI METROPOLITAN COUNCIL

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Author(s): Sani Ali Audu | David Bwala Ishaya | Alemika Emmanuel Taiwo | Musa A. Sani | Ilyas Mohammed

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 96;
Date: 2012;
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Keywords: Dexamethasone | Tablet | HPLC and UV-Spectrophotometer.

ABSTRACT
This experiment involves quantitative analysis of dexamethasone tablet marketed in Maiduguri Metropolitan Council using UV-Spectrophotometry and HPLC method of analysis in which the samples were dissolved in methanol and their absorbance were determined and compared to that of the standard. Percentage content for each of the samples was determined so as to note if it was within the acceptable range of 90-110% in the British Pharmacopoeia (BP), for those that passed the test or, if it was below or above the range for samples that are substandard or highly concentrated. The amount of dexamethasone tablet in each sample was determined (actual content) and compared with that of the stated amount (0.5mg). It was observed that out of the eight samples (AARON’S, KRIS, NKOYO, DEXAREL, LOKEL’S, ANISUN, CHAZMAX and DEXA) three of the samples (NKOYO, LOKEL’S and DEXA) met the BP requirement for actual drug content range of 90-110% with percentage content of 98.1, 99.2 and 95.8% respectively, while the other five samples failed the test with values below and above the acceptable range.
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