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Quantitative Analysis of Formation of Active Avoidance Behavior in the Hippocampus Coagulated and Intact White Albino Rats

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Author(s): Otar Tavdishvili | Nino G. Archvadze | Sulkhan N. Tsagareli

Journal: Journal of Biophysical Chemistry
ISSN 2153-036X

Volume: 02;
Issue: 01;
Start page: 10;
Date: 2012;
Original page

Keywords: Behavior | Learning | Memory | Active Avoidance | Hippocampus | Neocortex | Unsupervised Clustering

ABSTRACT
Unsupervised cluster analysis is proposed for analysis of active avoidance formation in three groups of albino rats: 1) intact; 2) with electrolytic lesions of neocortex over the dorsal hippocampus; and 3) with electrolytic lesions of dorsal hippocampus. The term “behavior vector” has been introduced to assess quantitatively the behavior of rats while learning. The proposed approach enables to assess active avoidance behavior in rats simultaneously by all the test parameters: 1) reaction to the light; 2) reaction to the electric irritation; and 3) inter-trial spontaneous behavior. The animals were grouped by their behavioral resemblance through the learning process. The proposed method facilitates the assessment of learning capacities in animals and paves way for getting additional information concerning correlative relationships between their learning skills and other neuroethological and neurobiological parameters.
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