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QUANTITATIVE DETERMINATION OF SILDENAFIL CITRATE IN COMMERCIAL TABLET DOSAGE FORM MARKETED IN MAIDUGURI METROPOLITAN COUNCIL (MMC)

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Author(s): Sani Ali Audu | Wole Ogunbameru | Musa A. Sani | Rafat Ojuolape Abdulraheem | Ramat B. Abdulraheem

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 91;
Date: 2012;
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Keywords: Sildenafil | HPLC | Ultra Violet Spectrophotometry.

ABSTRACT
A quantitative analysis was carried out to determine the claimed content of sildenafil citrate present in commercial tablet dosage forms of different brands, using the reference standard from the developed method for assay of sildenafil citrate. Nine different samples were analysed using HPLC and UV- Spectrophotometric method.For the HPLC and UV Spectrophotometer result, Pramo V has a percentage content of 103.7% and 102.6%, power 97.5 and 96.5% Man- up 95.2% and 96.9%, soga 104.2% and 104.6, caverta 101.9% and 100.2%, Homograe 102.8% and 100.5% , Teagra 99.0% and 98.4%, vega 91.3% and 91.4% and ceagra 109.1% and 114.4% , respectively. It was observed that both vega and ceagra samples has a percentage concentration of 91.3, 91.4% and 109.1% , 114.4% respectively. They thus failed the analysis test as the percentage content did not fall within the standard range of 95%-105%Based on the result obtained, about 78% of drugs that contain sildenafil citrate passed the analysis, while 22% failed.
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