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Quantitative and qualitative analysis of Ag-NOR in benign and malignant canine mammary gland tumors

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Author(s): Jelesijević Tomislav | Jovanović Milijana | Knežević Milijana A. | Aleksić-Kovačević Sanja

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 53;
Issue: 5-6;
Start page: 353;
Date: 2003;
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Keywords: dog | mammary gland | tumors | AgNOR

ABSTRACT
In this retrospective study, quantitative and qualitative analyses of argyrophil nucleolar organizer regions (AgNORs) in 54 malignant and 18 benign canine mammary gland tumors were made. Statistical analysis showed a significant difference in the mean number of AgNORs per cell between benign and malignant tumors (p0.05), as well as between adenomas and benign mixed tumors (p>0.05). Six different patterns of AgNOR distribution were observed. Types I, II, III and in only two cases, type IV, were observed in benign tumors, while all six types were observed in malignant tumors. The predominant types in malignant tumors were III, IV, V and VI. Cell types II, III and IV were predominant in malignant tumors with 5.5-7 AgNORs per cell, while cell types V and VI were dominant in tumors with more than 7 AgNORs per cell.
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