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Radon-therapy in ankylosing spondylitis reduces auto-antibody titers

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Author(s): Angelika Moder | Clemens Hufnagl | Martin Jakab | Wolfgang Hitzl | Markus Ritter

Journal: Open Journal of Molecular and Integrative Physiology
ISSN 2162-2159

Volume: 01;
Issue: 03;
Start page: 52;
Date: 2011;
Original page

Keywords: Radon | CCP | Autoantibodies | Ankylosing Spondylitis

ABSTRACT
Combined low-dose radon/hyperthermia therapy has been reported to improve pain and mobility in patients with rheumatic disorders. The key feature of inflammatory rheumatic diseases is the induction of autoimmune processes via the production of autoantibodies. As reducing the autoantibody level through administration of biologicals is described to correlate with delay of disease progression, we investigated the impact of combined low-dose radon/hyperthermia therapy on the serum levels of antibodies directed against cyclic citrullinated peptides in patients with ankylosing spondylitis. We found that levels of circulating anti-CCP antibodies is significantly reduced immediately after a 3 weeks of radon therapy regimen.
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