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Raised Interleukin-13 Levels in Cord Blood Increases the Risk of Allergic Sensitization at 5 Years of Age

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Author(s): Nevin Uzuner | Arzu Babayigit Hocaoglu | Duygu Olmez Erge | Suna Asilsoy | Ozkan Karaman | Zekiye Altun | Abdullah Kumral | Ozlem Tufekci | Huray Islekel

Journal: Iranian Journal Of Allergy, Asthma and Immunology
ISSN 1735-1502

Volume: 12;
Issue: 2;
Start page: 107;
Date: 2013;
Original page

Keywords: Allergy | Cord Blood | Interferon-Gamma | Interleukin-13

ABSTRACT
The identification of early markers of atopy in cord blood of newborns at delivery may offer prediction of future allergic sensitization. The aim of this study was to evaluate the relationship between cord blood interleukin-13 (IL-13) and interferon-gamma (IFN-γ) and development of allergic diseases during the first five years of life.Umbilical cord blood samples were collected at the time of delivery from 62 newborns. The families of these newborns were asked to complete a questionnaire about age and education of parents, number of siblings, allergic diseases in family members, cigarette exposure during pregnancy and presence of pets in their house. The same subjects were evaluated when they were five years old. Venous blood samples were drawn and epidermal skin prick tests were performed. IL-13 and interferon-gamma (IFN-γ) levels were studied from the blood samples which were taken during birth and five years later.There was no significant relationship between gender, type of delivery, educational levels of parents, exposure to cigarette smoke, atopy in parents, presence of pets in the house and IL-13 and IFN-γ levels in cord blood and at five years. Higher levels of IL-13 in newborns and five years olds, were found significantly related to skin prick test positivity (p=0.004 and p

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