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Raltegravir in combination with other antiretroviral agents for the treatment of HIV infection

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Author(s): Lisa M Chirch | Roy T Steigbigel

Journal: Infection and Drug Resistance
ISSN 1178-6973

Volume: 2010;
Issue: default;
Start page: 15;
Date: 2010;
Original page

ABSTRACT
Lisa M Chirch, Roy T SteigbigelDivision of Infectious Diseases, Department of Medicine, Stony Brook University Medical Center, Stony Brook, New York, USAAbstract: Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unusual given its recent availability, but resistance with identified viral mutation pathways in the integrase gene in patients receiving the drug does occur.Keywords: raltegravir, integrase, human immunodeficiency virus, drug resistance
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