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Rapid detection of anti-Vaccinia virus neutralizing antibodies

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Author(s): Kramski Marit | Drozd Anna | Lichtfuss Gregor | Dabrowski Piotr | Ellerbrok Heinz

Journal: Virology Journal
ISSN 1743-422X

Volume: 8;
Issue: 1;
Start page: 139;
Date: 2011;
Original page

ABSTRACT
Abstract Increasing infections with Monkeypox and Cowpox viruses pose a continuous and growing threat to human health. The standard method for detecting poxvirus neutralizing antibodies is the plaque-reduction neutralization test that is specific but also time-consuming and laborious. Therefore, a rapid and reliable method was developed to determine neutralizing antibody titers within twelve hours. The new assay measures viral mRNA transcription as a marker for actively replicating virus after incomplete neutralization using real-time PCR.

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Tangokurs Rapperswil-Jona

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