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A rare cause of diarrhea: Eosinophilic gastroenteritis

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Author(s): Abdullah Özgür Yeniova | Yaşar Nazlıgül | Feride Çağlar | Ayşe Kefeli | Metin Küçükazman | Gülçin Şimşek

Journal: Dicle Medical Journal
ISSN 1300-2945

Volume: 38;
Issue: 2;
Start page: 244;
Date: 2011;
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Keywords: eosinophilic gastroenteritis | diarrhea | eosinophilic infiltration

ABSTRACT
Eosinophilic gastroenteritis (EG) is a rare disease that is characterized by an eosinophil-driven inflammation of the digestive tract, presenting with gastrointestinal symptoms. In this report, a case of EG in an elderly man who presented with diarrhea was presented.A 68-year-old man admitted to hospital due to diarrhea, nausea, abdominal pain, and weight loss started two weeks ago. Hypereosinophilia were determined. Serum immunoglobulin E level was high. Stool examinations for intestinal parasites were negative. Biopsies were taken from esophagus, stomach, duodenum during upper and lower gastrointestinal endoscopies. Histopathological assessement showed an intense edema, eosinophilic and increased lymphoplasmasitic infiltration in lamina propria. Increased eosinophil count seen in bone-marrow biopsy, atypical cell was not seen. Eosinophilic gastroenteritis was considered and, ketotifen 2 mg/day and methylprednisolone 1 mg/kg/day were started. His symptoms were improved.Gastrointestinal symptoms of EG are nonspecific. The increase of eosinophilic cells in the circulating blood can suggest the possibility of EG. Definite diagnosis is made by histopathological assessment. Glucucorticoid therapy is the mainstay and is effective in the treatment of EG. However, the antihistamines are also used solely or combined with glucocorticoids.
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