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Recombinant human erythropoietin in sports: a review

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Author(s): Bento Rafael Maia de Almeida | Damasceno LĂșcia Menezes Pinto | Aquino Neto Francisco Radler de

Journal: Revista Brasileira de Medicina do Esporte
ISSN 1517-8692

Volume: 9;
Issue: 3;
Start page: 181;
Date: 2003;
Original page

Keywords: Erythropoietin | Epoetin | Peptidic hormones | Doping control

ABSTRACT
Erythropoietin is an endogenous hormone of glicoproteic nature secreted by the kidneys and is the main regulator of the erythropoiesis. An alteration in its production generates a disturbance in the plasmatic concentration giving rise to several types of pathologies related to the hematopoietic system. The recombinant forms of erythropoietin have indiscriminately been used by athletes, mainly in endurance sports, by increasing the erythrocytes concentration, generating a better delivery of oxygen to the muscle tissue. The administration of recombinant erythropoietin was prohibited by the International Olympic Committee and its use considered as doping. This review has the intention to describe the physical, biological and pharmacokinetic properties of the endogenous erythropoietin, as well as its recombinant form, describing also its use in sports and the process of searching methodologies for its detection in doping control.
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