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Reduced antioxidant defense in early onset first-episode psychosis: a case-control study

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Author(s): Micó Juan | Rojas-Corrales Maria | Gibert-Rahola Juan | Parellada Mara | Moreno Dolores | Fraguas David | Graell Montserrat | Gil Javier | Irazusta Jon | Castro-Fornieles Josefina | Soutullo Cesar | Arango Celso | Otero Soraya | Navarro Ana | Baeza Inmaculada | Martínez-Cengotitabengoa Mónica | González-Pinto Ana

Journal: BMC Psychiatry
ISSN 1471-244X

Volume: 11;
Issue: 1;
Start page: 26;
Date: 2011;
Original page

ABSTRACT
Abstract Background Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group. Methods Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls. Results A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients. Conclusions Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.
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